SMAD-INDEPENDENT BMP SIGNALING IN SOMATIC CELLS LIMITS THE SIZE OF THE GERMLINE STEM CELL POOL


Minimally invasive far lateral debridement combined with posterior instrumentation for thoracic and lumbar tuberculosis without severe kyphosis

Abstract Background Anti-tuberculous therapy (ATT) alone cannot easily cure spine tuberculosis (STB) though it is the most essential treatment.Many studies have confirmed the efficacy of the surgical treatment of STB through anterior, anterolateral, posterior debridement, and intervertebral fusion or combined with internal fixation.However, the con

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Applicability of an Ionising Radiation Measuring System for Real-Time Effective-Dose-Optimised Route Finding Solution during Nuclear Accidents

The reduction in the effective dose of evacuated injured persons through contaminated areas of nuclear accidents is an essential emergency services requirement.In this context, there appeared a need to develop a dose-optimised route finding method for firefighting rescue vehicles, which includes the development of a real-time decision support measu

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Protein Inhibitor of Activated STAT (PIAS) Negatively Regulates the JAK/STAT Pathway by Inhibiting STAT Phosphorylation and Translocation

Protein inhibitor of activated STAT (PIAS) proteins are activation-suppressing proteins for signal transducer and activator of transcription (STAT), which involves gene transcriptional regulation.The inhibitory mechanism of PIAS proteins in the Janus kinase (JAK)/STAT signaling pathway has been well studied in mammals and Drosophila.However, the ro

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